– His papacy included the Urabi Revolt, beginning the British occupation of Egypt that was supported by Khedive Tawfiq in February 1874 AD
– Boutros Ghali Pasha obtained an order from Khedive Ismail Pasha to establish the first Coptic General Religious Council in February 1874
– The Pope ordained a Coptic metropolitan for the Ethiopian Empire as well as four Ethiopian bishops who were scholars
– Built 13 churches in Cairo, Khartoum, and Giza, and established nine schools in Cairo and Giza. The dispute between the Pope and the Religious Council worsened, in which the council, by convincing Khedive Tawfiq, succeeded in distancing the Patriarch to the Baramous Monastery, however, the Pope returned to the throne by the Khedive’s order through the mediation of some zealous individuals
– Egyptian Revolution of 1919 took place, in which the Christians participated in and supported by Pope Kyrillos who he was in contact with Saad Zaghloul Pasha
– In his papacy, the Seminary and the Coptic Museum were established, and he ordained 44 bishops
– He lasted on the See of St. Mark 53 years, which is the longest period in the history of the Coptic Orthodox Church so far
